| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 13/03/25 18.45 | FC Lugano | NK Celje | 6:7d.c.r |
| 13/03/25 18.45 | KSV Cercle Brügge | Jagiellonia Bialystok | 2:0 |
| 13/03/25 18.45 | Djurgardens IF | Pafos FC | 3:0 |
| 13/03/25 18.45 | SK Rapid Vienna | FK Borac | 2:1d.t.s |
| 13/03/25 21.00 | Fiorentina | Panathinaikos Atene | 3:1 |
| 13/03/25 21.00 | FC Chelsea | FC Copenhagen | 1:0 |
| 13/03/25 21.00 | Legia Varsavia | Molde FK | 2:0d.t.s |
| 13/03/25 21.00 | Vitoria Guimaraes | Real Betis Siviglia | 0:4 |